DNA 02: Test for Hardy-Weinberg equilibrium
 

Three alleles {A1, A2, A3} at locus A were seen to occur in the observed numbers of genotypes in 600 people as in the table below (which is read, for example, as 60 people were observed to have the genotype A1/A2).

 

 

A1

A2

A3

A1

186

60

256

A2

 

6

38

A3

 

 

54

 

  1. Calculate the allele proportions at locus A.

  2. On the basis of your calculated proportions, estimate the numbers of each genotype that could be expected under Hardy-Weinberg equilibrium.

  3. Use the chi-squared test to test, at a significance level of 0.05, whether the observed population is likely to be in Hardy-Weinberg equilibrium.


Video Answer: Chi-squared = 6.47, No significant difference from HW equilibrium